De novo design of potent and selective interleukin mimetics

US11401313B2 · kind B2 · utility

Assignees

• University of Washington · US
• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Daniel Adriano Silva Manzano · Seattle, US
• Shawn Yu · Seattle, US
• Umut Ulge · Seattle, US
• David Baker · Ann Arbor, US
• Kenan Christopher Garcia · Menlo Park, US
• Jamie Spangler · Seattle, US
• Carl Walkey · Seattle, US

Key dates

• Filing date: Jun 23, 2020
• Grant date: Aug 2, 2022
• Expiry date: Jun 23, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αcheterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.