Methods for screening cereblon modifying compounds
US11402372B2 · kind B2 · utility
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Key dates
| Filing date | Jan 10, 2019 |
| Grant date | Aug 2, 2022 |
| Priority date | — |
| Expiry date | Dec 2, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/385
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.