Patent · US Active

Assays for detecting antibodies capable of mediating antibody-dependent cell-mediated cytotoxicity

US11402380B2 · kind B2 · utility

0Cited by

2References

16Claims

0Family size

Assignee

EMORY UNIVERSITY · US

Inventors

Paul Spearman · Cincinnati, US
Karnail Singh · Deerfield, US
Xuemin Chen · Tangxia, CN

Key dates

Filing date	Jan 25, 2019
Grant date	Aug 2, 2022
Priority date	—
Expiry date	Jan 25, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2760/14122
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

This disclosure relates to assays for detecting activating antibodies in a sample that are capable of antibody-dependent cell-mediated cytotoxicity. In certain embodiments, this disclosure relates to target cells comprising an antigen on the exterior of the cells and a luciferase inside the cells. In certain embodiments, the antigen is an Ebola-virus glycoprotein. In certain embodiments, this disclosure relates to detecting changes in chemiluminescence of the luciferase as an indication of activating antibodies in a sample capable of cell lysis when mixed with effector cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.