Amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscope
US11402620B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 31, 2019 |
| Grant date | Aug 2, 2022 |
| Priority date | — |
| Expiry date | Dec 31, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG02B21/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure relates a low magnification dark-field microscope system and method for producing a dark-field image. The method includes transferring a biological specimen to a surface of a sample plate, and pre-treating the biological specimen using one or more pre-treatment steps selected from (1) heating the biological specimen using a heating device; (2) applying ultrasound energy using an ultrasound transducer and ultrasound generator; and (3) doping the biological specimen with a metallic nanoparticle. Following pre-treatment, the method includes imaging a region of interest the biological specimen on the sample plate using a dark-field microscope to generate a dark-field image of the biological specimen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.