Nanocapsules and method for manufacturing thereof
US11406604B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 17, 2018 |
| Grant date | Aug 9, 2022 |
| Priority date | — |
| Expiry date | Apr 20, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/0093
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for manufacturing supported lipid bilayer on a porous silica nanoparticle with a ζ-potential comprised between −10 mV and +10 mV, the method comprising the steps of (a) providing a negatively charged supported lipid bilayer on a porous silica nanoparticle, wherein the negatively charged supported lipid bilayer has a ζ-potential inferior to −15 mV and wherein the negatively charged supported lipid bilayer comprised at least one phospholipid and; (b) adding a formulation of lipids, the lipids being 1,2-dioleoyl-3-trimethylammonium-propane alias DOTAP, cholesterol and at least one lipid different from DOTAP and cholesterol. The method further comprises the step of (c) performing an ultra-sonication for promoting DOTAP incorporation. The method can be supplemented by the step of addition of alginate and the step of cross-linking the alginate. Also a nanocapsule and composition comprising the nanocapsule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.