Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

US11406646B2 · kind B2 · utility

Assignees

• Virginia Commonwealth University · US
• Durect Corporation · US
• United States Government as represented by the Department of Veterans Affairs · US

Inventors

• Shunlin Ren · Richmond, US
• Leyuan Xu · Richmond, US
• Yanxia Ning · Richmond, US
• Jin Koung Kim · Richmond, US
• WeiQi Lin · Emerald Hills, US
• Andrew Miksztal · Palo Alto, US
• Hongwei Wu · Cupertino, US
• Min L. Lee · Saratoga, US

Key dates

• Filing date: Nov 10, 2020
• Grant date: Aug 9, 2022
• Expiry date: Nov 10, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J31/006
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions comprising 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.