Treatment of upper aerodigestive tract disorders and cough
US11406649B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Feb 14, 2019 |
| Grant date | Aug 9, 2022 |
| Priority date | — |
| Expiry date | Oct 29, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P11/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to a particular 1-di-alkyl-phosphinoyl-alkane, 1-(Diisopropyl-phosphinoyl)-nonane, referred to herein as “DIPA-1-9”. Surprisingly and unexpectedly, DIPA-1-9, is able to selectively treat (e.g., suppress) sensory discomfort arising from the lumenal epithelial lining of the pharynx and esophagus without side effects. Compared to structurally similar compounds, DIPA-1-9 did not have the problems of painful cold, stinging, or irritancy, or of adverse taste when applied in the oral cavity. To deliver the DIPA-1-9 to the lumenal epithelium of the pharynx and esophagus, an ideal formulation for delivery is a solution of DIPA-1-9 in syrup, at a concentration of 5 to 12 mg/mL and a delivery volume of less than 1 mL. The delivery unit can be a plastic vial with a design such that the syrup is poured onto the base of the tongue, next to the pillars of fauces. The DIPA-1-9 then reaches the nerve endings at the base of the epithelia and transduces signals of coolness and cold. Cooling of the pharyngeal and esophageal lining relieves discomfort and is useful for condit…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.