Telodendrimers and nanocarriers and methods of using same

US11406714B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Juntao Luo · Jamesville, US
• Wenzhe Huang · Fayetteville, US
• Yu Shao · Hsinchu, TW
• Changying Shi · Jamesville, US

Key dates

• Filing date: Aug 21, 2013
• Grant date: Aug 9, 2022
• Expiry date: Feb 6, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0054
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are functional segregated telodendrimers having, for example, two or three functional segments. The telodendrimers can have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.