Tricyclic compounds, compositions and medicinal applications thereof

US11407758B2 · kind B2 · utility

Assignee

• IMPETIS BIOSCIENCES LTD. · IN

Inventors

• Sujay Basu · Mumbai, IN
• Sachin Thorat · Pimpri-Chinchwad, IN
• Yogesh Shejul · Pimpri-Chinchwad, IN
• Anil Panmand · Pimpri-Chinchwad, IN
• Meena Patel · Libertyville, US
• Goraksha Khose · Mumbai, IN
• Rajesh Bonagiri · Pune, IN
• Dinesh Barawkar · Lake Forest, US
• Bheemashankar A. Kulkarni · Noida, IN
• Kasim Mookhtiar · Jamkhed, IN

Key dates

• Filing date: Jan 4, 2019
• Grant date: Aug 9, 2022
• Expiry date: Jan 4, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a series of tricyclic compounds, their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity. The disclosure also relates to process of preparation of these tricyclic compounds of Formula I. These compounds are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by antagonism of the adenosine receptor. The disclosure also relates to the process of preparation of the tricyclic compounds, and to pharmaceutical compositions containing them. Formula (I) wherein D represents a tricyclic ring system selected from: Formula (II) or Formula (III).