Equatorially modified polymer linked multimers of guanosine-3′, 5′-cyclic monophosphates

US11407781B2 · kind B2 · utility

Assignee

• Graybug Vision, Inc. · US

Inventors

• Hans-Gottfried Genieser · Lemwerder, DE
• Frank Schwede · Bremen, DE
• Andreas Rentsch · Bremen, DE
• Per EKSTRÖM · Lund, SE
• Valeria Marigo · Modena, IT
• Francois PAQUET-DURAND · Tübingen, DE

Key dates

• Filing date: Jun 29, 2017
• Grant date: Aug 9, 2022
• Expiry date: Jun 29, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/23
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3′, 5′-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related monomeric compounds, which may serve as monomeric precursors of the multimers, and/or also show itself inhibitory activity and/or impact the inhibitory activity of the related multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications, e.g., on chip surfaces.