Compositions and methods for biocontainment of microorganisms
US11408007B2 · kind B2 · utility
2Cited by
26References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 28, 2015 |
| Grant date | Aug 9, 2022 |
| Priority date | — |
| Expiry date | Nov 25, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/19
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (GMO) including the safeguards, and methods of use thereof are provided. The genetic safeguards generally impart a low escape frequency, are robust, and are modular. Safeguards with low escape frequency prevent the rise of mutants escaping defined media and limit growth in the wild. Robust safeguards retain wild-type levels of fitness while also maintaining containment in diverse growth conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.