Dielectric sensing to characterize hemostatic dysfunction

US11408844B2 · kind B2 · utility

Assignees

• CASE WESTERN RESERVE UNIVERSITY · US
• The United States Government as Represented by The Department of Veteran Affairs · US
• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Michael Suster · Cleveland, US
• Pedram Mohseni · Highland Heights, US
• Anirban Sen Gupta · Cleveland, US
• Matthew D. Neal · Pittsburgh, US
• Ujjal Didar Singh Sekhon · Cleveland, US
• Sanjay Ahuja · Katy, US
• Sina Pourang · Cleveland Heights, US
• Debnath Maji · Cleveland, US

Key dates

• Filing date: Apr 1, 2020
• Grant date: Aug 9, 2022
• Expiry date: Dec 1, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/4905
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

As one example, an apparatus includes a dielectric microsensor comprising a microfluidic chamber that includes a capacitive sensing structure, the microfluidic chamber including a fluid input port to receive a volume of a blood sample. A bioactive agent is disposed within the chamber to interact with the volume of the blood sample received in the microfluidic chamber. A transmitter provides an input radio frequency (RF) signal to an RF input of the dielectric microsensor. A receiver receives an output RF signal from an RF output of the dielectric microsensor. A computing device that computes dielectric permittivity values of the sample that vary over a time interval based on the output RF signal, the computing device to provide an assessment of hemostatic dysfunction and associated coagulopathy based on the dielectric permittivity values.