Devices, compositions and methods for imaging with Raman scattering

US11408894B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Wei Min · Edgewater, US
• Lu Wei · Daguantang, CN
• Zhixing Chen · Nanhu, CN
• FANGHAO HU · New York, US
• YIHUI SHEN · 安丰镇, CN

Key dates

• Filing date: Dec 17, 2019
• Grant date: Aug 9, 2022
• Expiry date: Dec 17, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/655
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.