Patent · US Active

Induced dendritic cells and uses thereof

US11413307B2 · kind B2 · utility

0Cited by

0References

6Claims

0Family size

Assignee

MEDIZINISCHE HOCHSCHULE HANNOVER · DE

Inventors

Renata Stripecke · Hannover, DE
Gustavo Salguero-Lopez · Hannöver, DE
Anusara Daenthanasanmak · Hannover, DE
Arnold Ganser · Hannover, DE

Key dates

Filing date	Apr 26, 2019
Grant date	Aug 16, 2022
Priority date	—
Expiry date	Jul 21, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2510/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to cells engineered to express at least one cytokine and at least one antigen which induces the self differentiation of dendritic cell (DC) progenitor cells into functional antigen-presenting induced DC (iDC). Moreover, therapeutic uses of said iDC for regenerating the immune system after transplantation of hematopoietic stem cells are disclosed. Said iDC are also useful for generating mice with a functional endogenously regenerated humanized immune system producing antigen-specific T and B cell responses which can be used as animal models for the study of the human adaptive immune responses.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.