Neuronal survival and axonal regeneration through increasing mitochondrial motility
US11413325B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Dec 7, 2017 |
| Grant date | Aug 16, 2022 |
| Priority date | — |
| Expiry date | Dec 7, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/708
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compositions and methods for promoting survival of or axon regeneration in neurons by increasing mitochondrial motility in the neuron. Also disclosed are methods to treat neuronal injury and disease and disorders characterized by neuronal injury. Agents that increase Armcx1 activity, such as Armcx1 polypeptide or vectors comprising nucleic acid encoding Armcx1 polypeptide, are proposed for use in the methods. Pharmaceutical composition comprising the agents, and methods for identifying additional agents are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.