Oxoacridinyl acetic acid derivatives and methods of use

US11414387B2 · kind B2 · utility

Assignee

• STINGTHERA, INC. · US

Inventors

• Brian T. Chamberlain · Cambridge, US
• James M. RICE · Wilmington, US
• Finith E. JERNIGAN, III · Wilmington, US
• Woody SHERMAN · Wilmington, US
• Meghana M. KULKARNI · Wilmington, US
• Sharon Shechter · Andover, US
• Bryce K. ALLEN · Wilmington, US
• Dazhi TAN · Wilmington, US
• Kristen A. MARINO · Wilmington, US
• Zhixiong LIN · Wilmington, US

Key dates

• Filing date: Jul 8, 2020
• Grant date: Aug 16, 2022
• Expiry date: Jul 8, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.