Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
US11414428B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Aug 25, 2016 |
| Grant date | Aug 16, 2022 |
| Priority date | — |
| Expiry date | Jul 4, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.