Patent · US Active

Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof

US11414661B2 · kind B2 · utility

7Cited by

3References

28Claims

0Family size

Assignee

SUZHOU RIBO LIFE SCIENCE CO., LTD. · CN

Inventors

Hongyan Zhang · Beijing, CN
Shan Gao · Beijing, CN
Daiwu KANG · Suzhou, CN
Lina KONG · Suzhou, CN

Key dates

Filing date	Nov 29, 2018
Grant date	Aug 16, 2022
Priority date	—
Expiry date	Nov 29, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3515
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are a siRNA for inhibiting the expression of an angiopoietin-like protein 3 (ANGPTL3) gene, and a pharmaceutical composition and a conjugate comprising the siRNA; wherein each nucleotide in the siRNA is independently a modified or unmodified nucleotide, and the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A, the nucleotide sequence A having the same length as the nucleotide sequence as represented by SEQ ID NO:1 with no more than 3 nucleotide differences; the antisense strand comprises a nucleotide sequence B, the nucleotide sequence B having the same length as the nucleotide sequence as represented by SEQ ID NO:2 with no more than 3 nucleotide differences.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.