TCR/BCR profiling using enrichment with pools of capture probes
US11414700B2 · kind B2 · utility
2Cited by
6References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 21, 2021 |
| Grant date | Aug 16, 2022 |
| Priority date | — |
| Expiry date | Apr 21, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/26
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein are systems, methods, and compositions useful for profiling T cell receptor (TCR) and B cell receptor (BCR) repertoire using next-generation sequencing (NGS) methods. In certain embodiments, the methods include enriching a sample for TCR/BCR RNA sequences, and determining the TCR/BCR profile of a subject using five different oligonucleotide pools. Also disclosed herein are systems and methods for diagnosing, treating, or predicting infection, disease, medical conditions, therapeutic outcome, or therapeutic efficacy based on the TCR/BCR profile data from a subject in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.