Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
US11414784B2 · kind B2 · utility
0Cited by
8References
20Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 21, 2019 |
| Grant date | Aug 16, 2022 |
| Priority date | — |
| Expiry date | Oct 28, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.