Non-human animal having human IL-34 and use Thereof
US11419317B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Mar 18, 2019 |
| Grant date | Aug 23, 2022 |
| Priority date | — |
| Expiry date | Mar 18, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0337
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
The present invention provides a non-human animal having human interleukin-34 (IL-34) in the body thereof; a method for producing a non-human animal having human microglia, which includes transplanting human CD34-positive hematopoietic stem cells into the non-human animal having human IL-34 in the body; and a method for producing human microglia, which includes obtaining human microglia from the non-human animal having human microglia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.