Genetically modified rat comprising a humanized TRKB locus
US11419318B2 · kind B2 · utility
1Cited by
7References
9Claims
0Family size
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Key dates
| Filing date | Nov 30, 2018 |
| Grant date | Aug 23, 2022 |
| Priority date | — |
| Expiry date | Nov 30, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/035
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.