Genetically modified rodent with an inducible ACVR1 mutation in exon 7 that causes ectopic bone formation
US11419319B2 · kind B2 · utility
1Cited by
5References
23Claims
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Key dates
| Filing date | Jun 12, 2019 |
| Grant date | Aug 23, 2022 |
| Priority date | — |
| Expiry date | Mar 9, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/30
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in anti sense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.