Means and methods for preventing and/or treating caries

US11419811B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Bruno Kaesler · Ludwigshafen, DE
• Rolf Knöll · Weinheim, DE
• Mewes Boettner · Berlin, DE
• Eckhard Budde · Cologne, DE
• Christine Lang · Berlin, DE
• Martin Ryser · Dresden, DE
• Markus Veen · Berlin, DE

Key dates

• Filing date: Sep 24, 2019
• Grant date: Aug 23, 2022
• Expiry date: Jan 17, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/225
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing sa…