Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom
US11419932B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 24, 2020 |
| Grant date | Aug 23, 2022 |
| Priority date | — |
| Expiry date | Feb 3, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions containing a nucleic acid nanostructure having a desired geometric shape and antigens bound to its surface are provided. The nanostructures can be, for example, in the form of a 6-helix bundle or icosahedron. The nanostructure design allows for control of the relative position and/or stoichiometry of the antigen bound to its surface. The antigens displayed on the nanostructure surface are arranged with the preferred number, spacing, and 3D organization to elicit a robust immune response. The displayed antigen can be an HIV immunogen such as eOD-GT6, eOD-GT8, or variants thereof. The compositions may thus be useful as immunogens, vaccines, immunostimulators, adjuvants, and the like. Methods of inducing immune responses, inducing protective immunity, inducing the production of neutralizing antibodies or inhibitory antibodies, inducing tolerance, and treating cancer, infectious or autoimmune diseases are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.