Method for preparing pregabalin intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid
US11420932B2 · kind B2 · utility
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Key dates
| Filing date | Dec 4, 2020 |
| Grant date | Aug 23, 2022 |
| Priority date | — |
| Expiry date | Dec 4, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for preparing pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting compound (I) 3-isobutylglutaric acid, as a raw material, with a nitrogen-containing agent to produce compound (II) 3-isobutylglutarimide; and performing stereoselective ring-opening of compound (II) under the action of a biological enzyme to produce compound (III) (R)-3-(carbamoylmethyl)-5-methylhexanoic acid:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.