Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto

US11421044B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Mark H. Schoenfisch · Chapel Hill, US
• Mona Jasmine R. Ahonen · Chapel Hill, US
• Lei Yang · Newton, US
• Haibao Jin · Carrboro, US
• Evan Scott Feura · Carrboro, US
• Sara Elizabeth Maloney · Chapel Hill, US

Key dates

• Filing date: Dec 23, 2019
• Grant date: Aug 23, 2022
• Expiry date: Dec 23, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/404
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions.