Chimeric and other variant beta-glucuronidase enzymes with enhanced properties
US11421210B2 · kind B2 · utility
2Cited by
13References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 8, 2019 |
| Grant date | Aug 23, 2022 |
| Priority date | — |
| Expiry date | Oct 8, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y302/01031
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Chimeric and other variant β-glucuronidase enzymes with enhanced properties as compared to unmodified enzyme are provided. The enzymes of the invention advantageously exhibit enhanced enzymatic activity, enhanced substrate range, enhanced pH range, enhanced temperature range and/or enhanced enzyme stability. Methods of using the variant enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.