Engineered tyrosine ammonia lyase
US11421253B2 · kind B2 · utility
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144References
20Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 14, 2021 |
| Grant date | Aug 23, 2022 |
| Priority date | — |
| Expiry date | Jan 14, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y403/01024
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced acid stability, while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.