Photonic structures and integrated device for detecting and analyzing molecules

US11422092B2 · kind B2 · utility

Assignee

• Quantum-Si Incorporated · US

Inventors

• Jonathan M. Rothberg · Paradise, US
• Ali Kabiri · Guilford, US
• Gerard Schmid · Guilford, US
• Keith G. Fife · Palo Alto, US
• James Beach · Austin, US
• Jason W. Sickler · Arlington, US
• Lawrence C. West · San Jose, US
• Paul E. Glenn · Wellesley, US
• Kyle Preston · Guilford, US
• Farshid Ghasemi · Guilford, US
• Benjamin Cipriany · Branford, US
• Jeremy Lackey · Foster City, US

Key dates

• Filing date: Jan 28, 2021
• Grant date: Aug 23, 2022
• Expiry date: Jan 28, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/6421
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.