Inhibition of JAK-STAT signaling inhibits formation of neutrophil extracellular traps (NETs)

US11426405B2 · kind B2 · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• Children's Medical Center Corporation · US

Inventors

• Rob Sellar · Newton, US
• Benjamin Ebert · Brookline, US
• Ofir Wolach · Boston, US
• Kimberly Martinod · Boston, US
• Denisa D. Wagner · Dover, US

Key dates

• Filing date: Dec 4, 2018
• Grant date: Aug 30, 2022
• Expiry date: Apr 9, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The methods described herein include methods for the treatment of subjects who have Clonal Hematopoiesis of Indeterminate Potential (CHIP) or a Philadelphia-negative myeloproliferative neoplasm (MPN), e.g., polycythaemia vera (PV) or essential thrombocythaemia (ET), using inhibitors of JAK-STAT signaling.