Patent · US Active

Antimicrobial agents against Staphylococcus aureus

US11427812B2 · kind B2 · utility

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37Claims

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Assignee

LYSANDO AG · LI

Inventors

Manfred Biebl · Regensburg, DE
Martin GRIESSL · Hohenschambach, DE
Kristin Neumann · Bamberg, DE

Key dates

Filing date	Nov 20, 2017
Grant date	Aug 30, 2022
Priority date	—
Expiry date	May 29, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/21
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to the field of antimicrobial agents active against Staphylococcus aureus bacteria. In particular, the present invention relates to polypeptides comprising the CHAP domain of LysK endolysin, the M23 endopeptidase domain of lysostaphin, the cell wall binding domain (CBD) of ALE-1, and a further peptide selected from the group consisting of an antimicrobial peptide, an amphipathic peptide, a cationic peptide, a hydrophobic peptide, a sushi peptide and a defensin. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells, compositions and devices. Finally, the present invention relates to applications of the inventive polypeptides, in particular in the pharmaceutical field.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.