Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids
US11427827B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Aug 14, 2019 |
| Grant date | Aug 30, 2022 |
| Priority date | — |
| Expiry date | Aug 14, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y501/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides systems and methods for increasing production of an alkaloid product through the epimerization of a (S)-1-benzylisoquinoline alkaloid to a (R)-1-benyzlisoquinoline alkaloid via an engineered epimerase in an engineered host cell. A (S)-1-benzylisoquinoline alkaloid is contacted with said engineered epimerase. Contacting said (S)-1-benzylisoquinoline alkaloid with said engineered epimerase converts said (S)-1-benzylisoquinoline alkaloid to said (R)-1-benzylisoquinoline alkaloid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.