Stable Fc binding protein, method for producing said protein, and antibody adsorbent in which said protein is used
US11427828B2 · kind B2 · utility
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Key dates
| Filing date | Apr 13, 2018 |
| Grant date | Aug 30, 2022 |
| Priority date | — |
| Expiry date | Feb 10, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/52
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn α chain and/or a β2 microglobulin region of a human FcRn β chain by another specific amino acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.