Patent · US Active

Method of improved sequencing by strand identification

US11427866B2 · kind B2 · utility

4Cited by

110References

16Claims

0Family size

Assignee

ACCURAGEN HOLDINGS LIMITED · KY

Inventors

Malek Faham · Pacifica, US
Shengrong Lin · Hayward, US
Ling Fung TANG · San Francisco, US
Yontao LU · Sunnyvale, US
Zhaohui Sun · Rochester, US
Yingyu Wang · Mountain View, US
Li Weng · Fremont, US

Key dates

Filing date	May 16, 2017
Grant date	Aug 30, 2022
Priority date	—
Expiry date	Mar 11, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2537/143
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

In some aspects, the present disclosure provides methods for identifying sequence variants, as well as methods of determining copy number of a genetic locus in a sample. Systems and kits for performing methods of the disclosure, as well as compositions produced by or useful in methods of the disclosure are also provided. In some embodiments, methods comprise extending 3′ ends of polynucleotides by adding one or more pre-determined nucleotides. In some embodiments, methods comprise use of a strand-tagging sequence.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.