Dry powder composition comprising long-chain RNA

US11433027B2 · kind B2 · utility

Assignee

• CureVac AG · DE

Inventors

• Fabian Johannes EBER · Stuttgart, DE
• Benyamin YAZDAN PANAH · Tübingen, DE
• Stefanie SEWING · Tübingen, DE
• Thomas Ketterer · Bingen, DE
• Thorsten MUTZKE · Reutlingen, DE
• Tilmann ROOS · Aspenhausiedlung, DE
• Michael Sonntag · Odenthal, DE
• Michael Wiggenhorn · Munich, DE
• Katharina KOLLAND · Augsburg, DE

Key dates

• Filing date: Aug 20, 2020
• Grant date: Sep 6, 2022
• Expiry date: Aug 20, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.