Polyacetal polymers, conjugates, particles and uses thereof

US11433136B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• Massachusetts Institute of Technology · US
• XTUIT Pharmaceuticals, Inc. · US

Inventors

• Peter Blume-Jensen · Newton, US
• Donald E. Chickering, III · Framingham, US
• Paul Kopesky · Quincy, US
• Lawrence Alan Reiter · Mystic, US
• Alan Crane · Newton, US
• Robert S. Langer · Newton, US
• Rong Tong · Singapore, SG
• Rakesh K. Jain · Penfield, US
• Vikash Pal Singh Chauhan · Boston, US
• Joao Incio · Boston, US
• Dai Fukumura · Newton, US

Key dates

• Filing date: Dec 16, 2016
• Grant date: Sep 6, 2022
• Expiry date: Oct 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G65/48
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are polymers, pH-sensitive polymers and/or linkers; conjugates comprising said polymers and/or linkers, optionally, coupled to one or more agents and/or targeting moieties; and particles (e.g., nanoparticles comprising the aforesaid polymers, linkers and/or conjugates), which can be used to enhance the delivery and/or efficacy of one or more agents in a subject.