Process and intermediates

US11434192B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Florian Karl Kleinbeck-Riniker · Basel, CH
• Benjamin Martin · Clermont-Ferrand, FR
• Gerhard Penn · Oberwil, CH
• Francesco VENTURONI · Basel, CH
• Thierry Schlama · Dardilly, FR
• Thomas Ruch · Frenkendorf, CH
• Thomas Allmendinger · Bad Kötzting, DE
• Bernhard Wietfeld · Weil am Rhein, DE
• Paolo Filipponi · Basel, CH

Key dates

• Filing date: Jun 25, 2019
• Grant date: Sep 6, 2022
• Expiry date: Jun 25, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.