Salt and polymorph of benzopyrimidinone compound and pharmaceutical composition and use thereof

US11434226B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. · CN
• TOPHARMAN SHANGHAI CO., LTD. · CN

Inventors

• Jingshan Shen · Shanghai, CN
• Yang He · Sichuan, CN
• Weiming Chen · Shanghai, CN
• Jianfeng Li · Qingdao, CN
• Guanghui Tian · 安丰镇, CN
• Xudong Gong · Ningbo City, CN
• Zhen Wang · Shanghai, CN
• Rongxia Zhang · Shanghai, CN
• Yongjian Liu · Chesterfield, US
• Hualiang Jiang · Shanghai, CN

Key dates

• Filing date: Jan 7, 2020
• Grant date: Sep 6, 2022
• Expiry date: Apr 3, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a salt of phenyl pyrimidinone compound, a polymorph thereof and a pharmaceutical composition comprising the same and a use thereof, particularly relates to the hydrochlorate of phenyl pyrimidinone compound of following formula (I-A) and a pharmaceutically acceptable polymorph, solvate, hydrate, co-crystal, anhydrous substance, or amorphous form thereof, a pharmaceutical composition and a pharmaceutical unit dosage comprising the same, the preparing method and use thereof.