Perfusion bioreactor with filtration systems
US11434464B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 11, 2021 |
| Grant date | Sep 6, 2022 |
| Priority date | — |
| Expiry date | Nov 11, 2041 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2317/06
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The disclosure provides a filtration system for a cell culture apparatus and a method of cell culture. The filtration system comprises a bioreactor vessel and two or more alternating tangential flow (ATF) filters connected in parallel. A failure in either filter is detected by an in-line sensor, and an automated response system functions to sequester the malfunctioning filter by stopping the flow of liquid media through the filter. Media flow through the remaining operable filters can be increased so that the rate of perfusion through the bioreactor remains relatively unchanged. Such a system may prevent issues that arise from ATF filter failures in conventional perfusion bioreactors, thereby improving the long-term viability of cell cultures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.