Nanotube trans-membrane channels mimicking biological porins

US11439708B2 · kind B2 · utility

Assignees

• Lawrence Livermore National Security, LLC · US
• The Regents of the University of California · US
• UNIVERSIDAD DEL PAIS VASCO · ES

Inventors

• Aleksandr Noy · Redwood City, US
• Jia Geng · Springfield, US
• Jianfei Zhang · Guilin, CN
• Vadim Frolov · Minas de Riotinto, ES

Key dates

• Filing date: Oct 5, 2015
• Grant date: Sep 13, 2022
• Expiry date: Oct 5, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/924
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is a nanopore structure, which in one aspect is a “carbon nanotube porin”, that comprises a short nanotube with an associated lipid coating. Also disclosed are compositions and methods enabling the preparation of such nanotube/lipid complexes. Further disclosed is a method for therapeutics delivery that involves a drug delivery agent comprising a liposome with a NT loaded with a therapeutic agent, introducing the therapeutic agent into a cell or a tissue or an organism; and subsequent release of the therapeutic agents into a cell.