Process for preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene

US11440861B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Karsten Koerber · Eppelheim, DE
• Michael Rack · Eppelheim, DE
• Pascal Bindschaedler · Münstermaifeld, DE
• Martin John McLaughlin · Bad Dürkheim, DE
• Birgit Gockel · Ludwigshafen, DE
• Devendra Vyas · Navi Mumbai, IN
• Sebastian Soergel · Ludwigshafen, DE

Key dates

• Filing date: Nov 25, 2019
• Grant date: Sep 13, 2022
• Expiry date: Nov 25, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C245/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene by diazotization and reduction of 6-bromo-2,4-dichloro-3-fluoro-aniline, which is obtained by bromination of 2,4-dichloro-3-fluoro-aniline, which is obtained by reduction of 1,3-dichloro-2-fluoro-4-nitro-benzene, and a process for preparing active compounds of formula V (Formula V) wherein the variables are defined in the specification by further transforming 5-bromo-1,3-dichloro-2-fluoro-benzene obtained from 2,4-dichloro-3-fluoro-aniline by the process according to the invention.