10H-phenothiazine ferroptosis inhibitor as well as the preparative method and the use thereof

US11440909B2 · kind B2 · utility

Assignee

• CHENGDU HENGHAO INVESTMENT CO. LIMITED · CN

Inventors

• Shengyong Yang · Shanghai, CN
• Linli Li · Lo Wu, CN

Key dates

• Filing date: Oct 23, 2020
• Grant date: Sep 13, 2022
• Expiry date: Oct 23, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

10H-phenothiazine derivatives capable of inhibiting ferroptosis has structural formula (I). The derivatives, pharmaceutically acceptable salts thereof, crystal forms thereof, or solvates thereof exhibit inhibitory effect on ferroptosis, and therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. The compounds and the inhibitors prepared by the compounds have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke.