Salts, crystal forms, and production methods thereof

US11440921B2 · kind B2 · utility

Assignee

• Sunovion Pharmaceuticals Inc. · US

Inventors

• Andrea Bauer · North Reading, US
• Nandkumar Nivritti BHOGLE · Shrewsbury, US
• Xiaoxia Chen · Beijing, CN
• Shahla Jamzad · Belmont, US
• Robert Joseph PRYTKO · Millbury, US
• Kostas Saranteas · Peabody, US
• Michael J. Sizensky · Grafton, US
• Harold Scott Wilkinson · Westborough, US
• Haitao Zhang · Ithaca, US

Key dates

• Filing date: Aug 28, 2020
• Grant date: Sep 13, 2022
• Expiry date: Aug 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.