3″,5″-dimethoxybenzoyl-3′-amino-3′-deoxy adenosine-5′-triphosphates and pharmaceutical uses thereof

US11440935B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Amir Pelleg · Haverford, US
• Anu Mahadevan · Westford, US
• Jie Li · Shanghai, CN
• Cynthia Morency · Andover, US

Key dates

• Filing date: Mar 14, 2019
• Grant date: Sep 13, 2022
• Expiry date: Mar 14, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H1/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compounds compound according to Formula (I), or a pharmaceutically acceptable salt, solvate, coordination complex or prodrug thereof: wherein, R1 and R2 are independently selected from (C1-C6) alkyl. The compounds have P2X3 receptor or P2X2/3 receptor antagonist activity and are useful for the treatment of diseases and disorders characterized by activation of those receptors.