Method for assaying the activity of spermidine/spermine N1-acetyltransferase
US11441168B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Aug 19, 2021 |
| Grant date | Sep 13, 2022 |
| Priority date | — |
| Expiry date | Aug 19, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57407
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for assaying activity of the enzyme spermidine/spermine N1-acetyltransferase (SSAT) uses SSAT substrates by detecting their acetylated forms. SSAT substrates may include rimantadine and tocainide wherein their metabolism occurs in part by the action of the inducible enzyme SSAT to produce the acetylated metabolites N-acetylrimantadine and N-acetyltocainide respectively. SSAT activity may be correlated to pathologic conditions.
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