Antibody producing non-human animals
US11445710B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Jan 12, 2018 |
| Grant date | Sep 20, 2022 |
| Priority date | — |
| Expiry date | Jul 30, 2038 |
Classification
- Technology area (CPC —)General
Abstract
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
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