Stable topical compositions of fenoldopam

US11446237B2 · kind B2 · utility

Inventors

• Helena Shifrin · Rehovot, IL
• Alexandra SHRAIFEL · Nahariah, IL
• Vered Rosenberger · Jerusalem, IL
• Ron SCHLINGER · Haifa, IL
• Tzviel SHESKIN · Haifa, IL
• Avi Avramoff · Haifa, IL

Key dates

• Filing date: Mar 6, 2020
• Grant date: Sep 20, 2022
• Expiry date: Mar 6, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P17/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure is directed to a topical composition, e.g., a physically and chemically stable topical composition of Fenoldopam comprising about 0.1% to about 5% by weight of Fenoldopam or a pharmaceutically acceptable salt thereof, at least one polyacrylamide-type gelling agent, at least one cellulose-type gelling agent, and at least one solvent, wherein the Fenoldopam is substantially solubilized in the composition, and wherein the composition is stable for at least twelve months at 25° C. and 60% relative humidity.