Aromatic 2-nitrosulfonyl fluoride antibiotics and methods of use thereof
US11446279B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Jun 27, 2018 |
| Grant date | Sep 20, 2022 |
| Priority date | — |
| Expiry date | Nov 25, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aspects of the present disclosure include antibacterial aromatic sulfonyl fluoride agents. The subject aromatic sulfonyl fluoride agents have a pharmacophore that can provide for potent antibacterial activity. The subject agents are compounds including an aromatic group substituted with a sulfonyl fluoride warhead group and an electron withdrawing group. The subject agents find use in a variety of antibiotic applications. In some cases, the subject agents find use in methods of treating bacterial infections in a subject. Also provided are pharmaceutical compositions and kits that find use in practicing the subject methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.