Patent · US Active

Non-platinum-based anti-cancer compounds for use in targeted chemotherapy

US11446294B2 · kind B2 · utility

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7Claims
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Inventor

Key dates

Filing dateSep 18, 2019
Grant dateSep 20, 2022
Priority date—
Expiry dateSep 18, 2039

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D241/20
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Disclosed herein are non-platinum-based (NPB) anti-cancer compounds useful for targeted chemotherapy, e.g., to generate anti-cancer effects for the treatment of cancer and other disorders while having no or minimal toxicity. The compounds have the general formula I: (I) wherein A represents an aromatic core; at least one of Ra and Rb is an electron transfer promoter as defined herein, e.g., NH2; and at least one of Rc is a leaving group as defined herein, e.g., halogen; and the remainder of the molecule is as defined herein. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the anti-cancer compounds are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.